5-Chloro-2-[(E)-2-[phenyl(pyridin-2-yl)methylidene]hydrazin-1-yl]pyridine
JIB-04
CAS: 199596-05-9
Molecular Formula: C17H13ClN4
5-Chloro-2-[(E)-2-[phenyl(pyridin-2-yl)methylidene]hydrazin-1-yl]pyridine - Names and Identifiers
5-Chloro-2-[(E)-2-[phenyl(pyridin-2-yl)methylidene]hydrazin-1-yl]pyridine - Physico-chemical Properties
| Molecular Formula | C17H13ClN4 |
| Molar Mass | 308.76 |
| Density | 1.24±0.1 g/cm3(Predicted) |
| Boling Point | 472.9±55.0 °C(Predicted) |
| Solubility | DMSO: 22.5 mg/mL |
| Appearance | powder |
| Color | white to beige |
| pKa | 11.00±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| In vitro study | Ji B- 04 causes transcriptional changes in a cancer-selective manner, including down-regulation of proliferative genes and up-regulation of anti-proliferative/pro-apoptotic genes. Ji B- 04 was able to block the proliferation of lung cancer, prostate cancer cell lines at IC50 levels as low as 10 nM, while producing less antiproliferative activity in HBECs and PrSCs/PrECs. |
| In vivo study | In two mouse xenograft models (H358 or A549), Ji B- 04 reduced tumor growth, reduced the activity of junonji histone demethylase in tumors, and prolonged the survival time of tumor patients. |
5-Chloro-2-[(E)-2-[phenyl(pyridin-2-yl)methylidene]hydrazin-1-yl]pyridine - Risk and Safety
| WGK Germany | 3 |
5-Chloro-2-[(E)-2-[phenyl(pyridin-2-yl)methylidene]hydrazin-1-yl]pyridine - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.239 ml | 16.194 ml | 32.387 ml |
| 5 mM | 0.648 ml | 3.239 ml | 6.477 ml |
| 10 mM | 0.324 ml | 1.619 ml | 3.239 ml |
| 5 mM | 0.065 ml | 0.324 ml | 0.648 ml |
Last Update：2024-01-02 23:10:35
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Featured ProductsSpot supply
Product Name: JIB-04(NSC 693627) Visit Supplier Webpage Request for quotationCAS: 199596-05-9
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: JIB-04 Visit Supplier Webpage Request for quotationCAS: 199596-05-9
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: JIB-04 Visit Supplier Webpage Request for quotationCAS: 199596-05-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: JIB-04 Visit Supplier Webpage Request for quotationCAS: 199596-05-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
5-Chloro-2-[(E)-2-[phenyl(pyridin-2-yl)methylidene]hydrazin-1-yl]pyridine
1H-Pyrrolo[2,3-b]pyridine-2-carboxaldehyde, 1-[(4-methylphenyl)sulfonyl]-
purin-6(1H)-one
PROTOCATECHUIC ACID 3-METHYL ETHER
Quinaldine
1H-Pyrrolo[2,3-b]pyridine-2-carboxaldehyde, 1-[(4-methylphenyl)sulfonyl]-
purin-6(1H)-one
PROTOCATECHUIC ACID 3-METHYL ETHER
Quinaldine